Abstracts: Pyrimidine, which is one of the bases of hydrolyzed product of nucleosides is an interesting subject for a medicinal chemist by virtue of its diverse biological activities. Uric acid and its oxidation product, alloxan are among the oldest pyrimidine derivatives of biological interest. Various pyrimidines have been reported as anti inflammatory, analgesic, anti microbial, antiparasitic, and antihistaminic agents. In present scheme, an attempt has been made to synthesize some novel pyrimidine derivatives. The starting compound pyrimidine was synthesized by condensation of various aromatic aldehydes, ethyl cyano acetate, guanidine hydrochloride and NaOH in presence of ethanol. Then those pyrimidine derivatives were subjected benzoylation by using benzoyl chloride, triethyl amine and ethanol. The benzoylated pyrimidine derivatives were treated with phosphorous pentachloride to form chloramino pyrimidine derivatives. Then these chloramino pyrimidine derivatives were treated with sodium azide and sodium acetate in aqueous acetone to yield benzyl tetrazole pyrimidine derivatives. The synthesized compounds were characterized and confirmed by melting point, TLC, IR, 1H NMR and mass spectroscopy and then screened for analgesic and antimicrobial activity. Many compounds have shown promising activity while others were inactive.
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